Pharmacokinetics of Dapivirine Vaginal Ring during Ring Removals and Re-insertions

HIV prevention methods should consider circumstances of non-adherence to evaluate effectiveness. The effect of multiple removals and (re-)insertions of Dapivirine Vaginal Ring at different time points during a 28-day period on local and systemic dapivirine exposure and dapivirine residual levels in used rings was evaluated to simulate possible scenarios of product non-adherence by women in Phase III clinical trials.

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