
In January 2020, hVIVO merged with Open Orphan plc, a rapidly growing niche CRO pharmaceutical services company.
On 26 October 2022, Open Orphan plc changed its name to hVIVO plc to maximise its brand recognition as the world leader in human challenge trials. hVIVO is now the parent company of both Venn Life Sciences, and CRS. Venn is an integrated drug development consultancy, offering CMC (chemistry, manufacturing and controls), preclinical, Phase I & II clinical trials design and execution (including data management and statics management. More recently, in 2025 hVIVO acquired CRS, CRS specialises in early phase clinical development, from First-in-Human and proof of concept studies. Together, the companies offer a full-service solution, from consultancy and drug development, to running phase I First-in-Human studies to human challenge model trials.
Building on decades of unrivalled experience, we provide world class expertise and capabilities in challenge agent manufacture, a unique portfolio of established human challenge models to test a broad range of infectious and respiratory disease products, CL2 and CL3 specialist laboratory services and specialist drug development and clinical consultancy services.

hVIVO is a full-service early phase Contract Research Organisation (CRO) offering end-to-end drug development services from preclinical consultancy through to Phase III clinical trials and the world leader in testing infectious and respiratory disease vaccines and therapeutics using human challenge clinical trials.
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CRS is a leading early phase CRO with state-of-the-art research units in Germany, excelling in innovative solutions for early clinical development, from First-in-Human studies to Proof-of-Concept trials in patients.
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hLAB is a highly specialised infectious disease and immunology laboratory offering a suite of services to support pre-clinical and drug and vaccine discovery & development.
Through the acquisition of Cryostore™, hLAB have extended their storage offering to the biotech and pharmaceutical industries with locations in London and Cambridge. Crystore™ is a dedicated GxP storage facility for biological and clinical materials in secure temperature-controlled conditions.


Flucamp welcomes participants to take part in our clinical trials under expertly supervised conditions.
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