Scientific Publications

Recent Scientific Publications

Venn’s Medical and Methodology Team will continue to manage its commitment of working collaboratively with our clients and building on its past successes throughout 2020 (https://www.vennlifesciences.com/methodology-study-design-biostatistics-consulting/). As 2019 draws to a close, we are looking back at two recent scientific publications co-authored with a client, involving two members of our Medical and Methodology team.

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis.

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis. The Venn Team partnered with one of our clients for a Phase 2 (117 patients, 18 sites, 7 countries), randomized, 28 weeks double-blind, placebo-controlled trial to determine the effect of recombinant human pentraxin 2 vs. placebo in patient with IPF. The randomized part of the study was followed by a long term open-label extension, were all patients received the active treatment.
The results of the 28 weeks randomized double blind placebo-controlled part of the study were published in the Journal of the American Medical Association (JAMA) in 2018: Raghu et al, Effect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis A Randomized Clinical Trial, JAMA. 2018;319(22):2299-2307: https://jamanetwork.com/journals/jama/article-abstract/2681945?widget=personalizedcontent&previousarticle=2681942) and is co-authored by one of our Venn’s Biometrics and Methodology Consultant, Hugues Santin-Janin.

The long-term open-label extension interim results were then published in The Lancet Respiratory Medicine in 2019, with Hugues Santin-Janin and Francois Aubin as co-authors: Raghu et al, Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary fibrosis: an open-label extension study, The Lancet Respiratory Medicine 2019, 7, (8): 657-664: http://dx.doi.org/10.1016/S2213-2600(19)30172-9).