COURSE: Pharmacokinetics Course
Face to face sessions replaced by remote training.
New training dates: to be announced soon – Online : Price: €1,850
Registration now open, click here to register your interest and find out more
Pharmacokinetics (PK) is generally referred to as ‘what the body does to the drug’ versus ‘what the drug does to the body’ (pharmacodynamics [PD]). Pharmacokinetics describes the fate, or time course, of an administered drug within the body. The physiological processes that determine the time course of the drug are Absorption, Distribution, Metabolism and Elimination (ADME). Both the desired effects and undesired effects of a drug are related to the drug levels in the body. The pharmacokinetic properties of a drug determine these levels. Ultimately, the optimal dose and dosing regimen to reach the desired or therapeutic drug levels are determined by means of pharmacokinetics.
This course will focus on the physiochemical properties underlying the pharmacokinetics of a drug, will give insight in the calculation and interpretation of the pharmacokinetic parameters and will also explain the importance and application of pharmacokinetics in preclinical and clinical drug development.
Who should attend?
You are interested in pharmacokinetics (or toxicokinetics), either because you started a career in drug development or in pharmacokinetics, you regularly interact with others working in pharmacokinetics, or simply because you want to broaden your knowledge on this topic.
What does the program cover?
During this course you will get familiar with at least the following subjects:
Understanding of biological processes underlying pharmacokinetics
- Absorption, including passive diffusion and active drug transport
- Distribution, including tissue distribution and plasma protein binding
- Metabolism, including enzymatic transformation, inhibition and induction
- Elimination, including renal excretion
Calculation and interpretation of pharmacokinetic parameters
- Pharmacokinetics after a single IV dose
- Pharmacokinetics after an extravascular dose
- Pharmacokinetics after repeated dosing
- Urinary pharmacokinetic parameters
- Linear versus non-linear pharmacokinetics
- Interpreting volume of distribution and clearance
- The role of pharmacokinetics in preclinical and clinical drug development
- Pharmacokinetics in practice: Case study
- General introduction into pharmacokinetic / pharmacodynamic modeling
This course will be a mixture of theoretical background, real-life examples and practical exercises.
Key Learning Objectives:
Upon completion of this course you will be familiar with the pharmacokinetic concepts and the underlying physiochemical processes. You will be able to effectively interpret pharmacokinetic information and put it into the context of drug development.
After this course you will receive a certificate of participation.
The costs of this course is €1,850.- (excl. VAT) for four days.
For attendees from universities, academic institutions or governmental authorities there is a reduced fee of €950.00 – (excl. VAT).
Timing & Location:
Due to Covid-19 restrictions, this course is now scheduled to take place online over 4 days. Maximum of 25 participants. New dates to be announced soon.